The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats.
نویسندگان
چکیده
The Noc1-4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1-4p are largely comprised of alpha-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins.
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عنوان ژورنال:
- RNA
دوره 10 3 شماره
صفحات -
تاریخ انتشار 2004